Research and industrialization progress of immunosuppressant mycophenolic acid

Abstract:

Mycophenolic acid is one of the most widely used immunosuppressant in the world, and the market demand is huge. So far, the industrial production of mycophenolic acid is mainly through fungal fermentation, and the strains used for production are mostly mutagenized high-yielding Penicillium brevicompactum. This article systematically reviews the research and industrialization progress of mycophenolic acid. Five aspects including current research and application of mycophenolic acid, chemical synthesis and biosynthetic pathways, genetic regulation, fermentation production and market analysis are described. This review will provide valuable information for the development of novel derivatives of the drug, the improvement of yield, and the intelligent creation of advanced biotechnology in the future.

Key words:mycophenolic acid;biosynthesis;regulatory pathway;fermentation