Progress on the DeoR family transcriptional regulators in bacteria

Abstract:

There are a large number of transcriptional regulator families in bacterial genomes, which play a crucial role in the growth, metabolism, and external signal perception and transmission of bacteria. Deoxyribonucleoside operon repressor (DeoR) family, a category of transcriptional regulators ubiquitous in prokaryotes, is mainly involved in the regulation of multiple physiological processes, including nucleotide metabolism, sugar metabolism, pathogenesis, and secondary metabolism. The ligand-binding domain at the C-terminus of DeoR usually responds to phosphorylated intermediate of the corresponding metabolic pathway. This paper reviewed the structural features, regulatory function, and ligands of DeoR family transcriptional regulators in bacteria, aiming to help researchers to decipher the regulatory mechanisms of DeoR proteins.

Key words:deoxyribonucleoside operon repressor;structural feature;regulatory function;target sequence;ligand