Role of NLRP6 in infectious and non-infectious diseases

doi:10.13343/j.cnki.wsxb.20210452

Home > Archive>Volume 62, Issue 4, 2022 >1190-1201. DOI:10.13343/j.cnki.wsxb.20210452

Role of NLRP6 in infectious and non-infectious diseases
DOI:
                        10.13343/j.cnki.wsxb.20210452
                    
CSTR:
                        32112.14.j.AMS.20210452
                    
Author:
                        TAO QiTAO Qi
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China
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XU DongyiXU Dongyi
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China
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FANG RendongFANG Rendong
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China;Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China
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Abstract:

Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 6(NLRP6) is a member of the NOD-like receptor (NLR) family.It participates in inflammasome assembly to mediate the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18.In addition,it plays an important role in host innate immune response to pathogen,maintaining intestinal epithelial integrity,and regulating metabolic diseases and neuroinflammation.In this paper,we reviewed the activation and regulation mechanism of NLRP6 inflammasome,as well as the role of NLRP6 in infectious and non-infectious diseases.

Key words:NLRP6;inflammasome;host defense

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TAO Qi, XU Dongyi, FANG Rendong. Role of NLRP6 in infectious and non-infectious diseases. [J]. Acta Microbiologica Sinica, 2022, 62(4): 1190-1201

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Received:July 30,2021
Revised:September 16,2021
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Online: April 15,2022
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