Home > Archive>Volume 62, Issue 4, 2022 >1216-1230. DOI:10.13343/j.cnki.wsxb.20210459
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Research progress of drugs and vaccines against enterovirus 71
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    Abstract:

    Hand-foot and mouth disease (HFMD),as a disease of global concern,occurs frequently in Asia and its harm cannot be underestimated.The multiple transmission routes,strong infectivity,induction of complications,diverse pathogenic strains and easy variation bring challenges to the prevention and treatment of HFMD.Enterovirus 71(EV71) is one of the main pathogens causing HFMD.Since there is no specific drug against EV71,it is of great significance to find appropriate therapeutic drugs.We summarize the research progress of drugs and vaccines against EV71,aiming to give insights into the prevention and control of HFMD.

    Reference
    [1] Fu XM, Wan ZZ, Li YP, Hu YH, Jin X, Zhang CY. National epidemiology and evolutionary history of four hand, foot and mouth disease-related enteroviruses in China from 2008 to 2016. Virologica Sinica, 2020, 35(1):21-33.
    [2] Yu FY, Zhu RN, Jia LP, Song QW, Deng J, Liu LY, Zhao LQ, Qian Y. Sub-genotype change and recombination of coxsackievirus A6s may be the cause of it being the predominant pathogen for HFMD in children in Beijing, as revealed by analysis of complete genome sequences. International Journal of Infectious Diseases, 2020, 99:156-162.
    [3] Bian LL, Wang YP, Yao X, Mao QY, Xu M, Liang ZL. Coxsackievirus A6:a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. Expert Review of Anti-Infective Therapy, 2015, 13(9):1061-1071.
    [4] Lim CTK, Jiang L, Ma S, James L, Ang LW. Basic reproduction number of coxsackievirus type A6 and A16 and enterovirus 71:estimates from outbreaks of hand, foot and mouth disease in Singapore, a tropical city-state. Epidemiology and Infection, 2016, 144(5):1028-1034.
    [5] Kou ZQ, Jia J, Liu XH, Luo TT, Xin XL, Gong JL, Zhang JF, Sun DP, Jiang FC, Gao RQ. Epidemiological characteristics and spatial-temporal clusters of hand, foot and mouth disease in Qingdao City, China, 2013-2018. PLoS One, 2020, 15(6):e0233914.
    [6] Qian HK, Huo D, Wang XL, Jia L, Li XT, Li J, Gao ZY, Liu BW, Tian Y, Wu XN, Wang QY. Detecting spatial-temporal cluster of hand foot and mouth disease in Beijing, China, 2009-2014. BMC Infectious Diseases, 2016, 16:206.
    [7] Jiang FC, Yang F, Chen L, Jia J, Han YL, Hao B, Cao GW. Meteorological factors affect the hand, foot, and mouth disease epidemic in Qingdao, China, 2007-2014. Epidemiology and Infection, 2016, 144(11):2354-2362.
    [8] Woodland DL. Hand, foot, and mouth disease. Viral Immunology, 2019, 32(4):159.
    [9] Wang XM, Zhu CF, Bao WG, Zhao K, Niu JQ, Yu XF, Zhang WY. Characterization of full-length enterovirus 71 strains from severe and mild disease patients in northeastern China. PLoS One, 2012, 7(3):e32405.
    [10] Wang JY, Teng Z, Cui XQ, Li CS, Pan H, Zheng YX, Mao SH, Yang YY, Wu LM, Guo XK, Zhang X, Zhu YZ. Epidemiological and serological surveillance of hand-foot-and-mouth disease in Shanghai, China, 2012-2016. Emerging Microbes& Infections, 2018, 7(1):1-12.
    [11] 周立新,李轶男,麦志广,强新华,汪首振,誉铁鸥,方滨,温伟标.危重型手足口病合并急性肺水肿患儿的临床特点.中华危重病急救医学, 2015(7):563-567. Zhou LX, Li YN, Mai ZG, Qiang XH, Wang SZ, Yu TO, Fang B, Wen WB. Clinical feature of severe hand, foot and mouth disease with acute pulmonary edema in pediatric patients. Chinese Critical Care Medicine, 2015(7):563-567.(in Chinese)
    [12] Schmidt NJ, Lennette EH, Ho HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. The Journal of Infectious Diseases, 1974, 129(3):304-309.
    [13] Shen WC, Chiu HH, Chow KC, Tsai CH. MR imaging findings of enteroviral encephaloymelitis:an outbreak in Taiwan. AJNR American Journal of Neuroradiology, 1999, 20(10):1889-1895.
    [14] Chen MM, Ju Y, Chen M, Xie ZG, Zhou KJ, Tan Y, Mo JJ. Epidemiological and genetic characteristics of EV71 in hand, foot, and mouth disease in Guangxi, Southern China, from 2010 to 2015. PLoS One, 2017, 12(12):e0188640.
    [15] McMinn PC. Recent advances in the molecular epidemiology and control of human enterovirus 71 infection. Current Opinion in Virology, 2012, 2(2):199-205.
    [16] Yi LN, Lu J, Kung HF, He ML. The virology and developments toward control of human enterovirus 71. Critical Reviews in Microbiology, 2011, 37(4):313-327.
    [17] Xu LZ, Qi MD, Ma CL, Yang MM, Huang P, Sun J, Shi JD, Hu YZ. Natural intertypic and intratypic recombinants of enterovirus 71 from mainland China during 2009-2018:a complete genome analysis. Virus Genes, 2021, 57(2):172-180.
    [18] Too IHK, Yeo H, Sessions OM, Yan B, Libau EA, Howe JLC, Lim ZQ, Suku-Maran S, Ong WY, Chua KB, Wong BS, Chow VTK, Alonso S. Enterovirus 71 infection of motor neuron-like NSC-34 cells undergoes a non-lytic exit pathway. Scientific Reports, 2016, 6:36983.
    [19] Chang CY, Li JR, Ou YC, Chen WY, Liao SL, Raung SL, Hsiao AL, Chen CJ. Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells. IUBMB Life, 2015, 67(10):789-800.
    [20] Luo Z, Su R, Wang WB, Liang YC, Zeng XF, Shereen MA, Bashir N, Zhang Q, Zhao L, Wu KL, Liu YL, Wu JG. EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production. PLoS Pathogens, 2019, 15(11):e1008142.
    [21] You L, Chen JB, Liu WY, Xiang Q, Luo Z, Wang WB, Xu W, Wu KL, Zhang Q, Liu YL, Wu JG. Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation. Virulence, 2020, 11(1):537-553.
    [22] Hu YJ, Xu YY, Huang ZM, Deng Z, Fan JY, Yang RA, Ma HY, Song J, Zhang YH. Transcriptome sequencing analysis of SH-SY5Y cells infected with EV71 reveals the potential neuropathic mechanisms. Virus Research, 2020, 282:197945.
    [23] Shang J, Zheng Y, Mo JY, Wang WB, Luo Z, Li YK, Chen XL, Zhang QW, Wu KL, Liu WY, Wu JG. Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks. Virulence, 2021, 12(1):704-722.
    [24] Cheng ML, Chien KY, Lai CH, Li GJ, Lin JF, Ho HY. Metabolic reprogramming of host cells in response to enteroviral infection. Cells, 2020, 9(2):473.
    [25] Gao WY, Hou M, Liu X, Li ZL, Yang YJ, Zhang WY. Induction of SOCS expression by EV71 infection promotes EV71 replication. BioMed Research International, 2020, 2020:2430640.
    [26] Du HW, Yin PQ, Yang XJ, Zhang LL, Jin Q, Zhu GF. Enterovirus 712C protein inhibits NF-κB activation by binding to RelA (p65). Scientific Reports, 2015, 5:14302.
    [27] Wen WH, Qi ZX, Wang J. The function and mechanism of enterovirus 71(EV71)3C protease. Current Microbiology, 2020, 77(9):1968-1975.
    [28] Gunaseelan S, Chu JJH. Identifying novel antiviral targets against enterovirus 71:where are we?Future Virology, 2017, 12(4):171-191.
    [29] Wang B, Li JL, Wang Y, Du N, Sun LY, Xiao HM, Zhao Y, Bao WG, Zhang WY. Understanding the epidemiological characteristics of EV71 and CVA16 infection to aid the diagnosis and treatment of hand, foot, and mouth disease. Journal of Medical Virology, 2019, 91(2):201-207.
    [30] Xu Y, Wu YF, Luo HH, Zhang DD, Wu Y, Hu P. Acute kidney injury secondary to severe hand, foot and mouth disease caused by enterovirus-A71:hypertension is a common. Journal of Tropical Pediatrics, 2018, 65(5):510-513.
    [31] Casaos J, Gorelick NL, Huq S, Choi J, Xia YX, Serra R, Felder R, Lott T, Kast RE, Suk I, Brem H, Tyler B, Skuli N. The use of ribavirin as an anticancer therapeutic:will it go viral?Molecular Cancer Therapeutics, 2019, 18(7):1185-1194.
    [32] Tate PM, Mastrodomenico V, Mounce BC. Ribavirin induces polyamine depletion via nucleotide depletion to limit virus replication. Cell Reports, 2019, 28(10):2620-2633.e4.
    [33] Cursino CN, Monteiro P, Duarte G, Vieira TBQ, Crisante VC, Giordani F, Xavier AR, De Almeida RMVR, Calil-Elias S. Predictors of adverse drug reactions associated with ribavirin in direct-acting antiviral therapies for chronic hepatitis C. Pharmacoepidemiology and Drug Safety, 2019, 28(12):1601-1608.
    [34] Yen TY, Shih WL, Huang YC, Lee JT, Huang LM, Chang LY. Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. PLoS One, 2018, 13(11):e0206769.
    [35] Chang CK, Wu SR, Chen YC, Lee KJ, Chung NH, Lu YJ, Yu SL, Liu CC, Chow YH. Mutations in VP1 and 5'-UTR affect enterovirus 71 virulence. Scientific Reports, 2018, 8:6688.
    [36] Ren XX, Li C, Xiong SD, Huang Z, Wang JH, Wang HB. Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death. Virulence, 2015, 6(8):802-808.
    [37] Li YP, Wang MQ, Liu CR, Deng HL, Wu Y, Dang SS, Xu LH. Polymorphisms in the DC-SIGN gene and their association with the severity of hand, foot, and mouth disease caused by enterovirus 71. Archives of Virology, 2021, 166(4):1133-1140.
    [38] Ren XX, Ma L, Liu QW, Li C, Huang Z, Wu L, Xiong SD, Wang JH, Wang HB. The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection. Virology Journal, 2014, 11:47.
    [39] 张莉,许中,沈东华,张剑峰. DC-SIGN受体促进肠道病毒71型体外感染树突状细胞.临床检验杂志, 2019, 37(4):274-277. Zhang L, Xu Z, Shen DH, Zhang JF. DC-SIGN molecules promote EV71 infection in dendritic cells in vitro. Chinese Journal of Clinical Laboratory Science, 2019, 37(4):274-277.(in Chinese)
    [40] Zhou DM, Zhao YG, Kotecha A, Fry EE, Kelly JT, Wang XX, Rao ZH, Rowlands DJ, Ren JS, Stuart DI. Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2. Nature Microbiology, 2019, 4(3):414-419.
    [41] Jin YF, Sun TT, Zhou GY, Li D, Chen SY, Zhang WG, Li XY, Zhang RG, Yang HY, Duan GC. Pathogenesis study of enterovirus 71 using a novel human SCARB2 knock-in mouse model. mSphere, 2021, 6(2):e0104820.
    [42] Zhang XY, Yang P, Wang N, Zhang JL, Li JY, Guo H, Yin XY, Rao ZH, Wang XX, Zhang LG. The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein& Cell, 2017, 8(8):590-600.
    [43] Martínez-Salas E. The impact of RNA structure on picornavirus IRES activity. Trends in Microbiology, 2008, 16(5):230-237.
    [44] Xi JM, Ye F, Wang GZ, Han W, Wei ZZ, Yin B, Yuan JG, Qiang BQ, Peng XZ. Polypyrimidine tract-binding protein regulates enterovirus 71 translation through interaction with the internal ribosomal entry site. Virologica Sinica, 2019, 34(1):66-77.
    [45] Su YS, Tsai AH, Ho YF, Huang SY, Liu YC, Hwang LH. Stimulation of the internal ribosome entry site (IRES)-dependent translation of enterovirus 71 by DDX3X RNA helicase and viral 2A and 3C proteases. Frontiers in Microbiology, 2018, 9:1324.
    [46] Davila-Calderon J, Patwardhan NN, Chiu LY, Sugarman A, Cai ZG, Penutmutchu SR, Li ML, Brewer G, Hargrove AE, Tolbert BS. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nature Communications, 2020, 11:4775.
    [47] Gunaseelan S, Wong KZ, Min N, Sun JL, Ismail NKBM, Tan YJ, Lee RCH, Chu JJH. Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection. Science Translational Medicine, 2019, 11(516):eaar5759.
    [48] Ma HY, Lu CY, Tsao KC, Shih HM, Cheng AL, Huang LM, Chang LY. Association of EV713C polymorphisms with clinical severity. Journal of Microbiology, Immunology and Infection, 2018, 51(5):608-613.
    [49] Li J, Yao YF, Chen Y, Xu X, Lin YQ, Yang ZL, Qiao WT, Tan J. Enterovirus 713C promotes apoptosis through cleavage of PinX1, a telomere binding protein. Journal of Virology, 2017, 91(2):e0201616.
    [50] Li ML, Lin JY, Chen BS, Weng KF, Shih SR, Calderon JD, Tolbert BS, Brewer G. EV713C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation. PLoS One, 2019, 14(9):e0221048.
    [51] Yao CG, Xi CL, Hu KH, Gao W, Cai XF, Qin JL, Lv SY, Du CH, Wei YH. Inhibition of enterovirus 71 replication and viral 3C protease by quercetin. Virology Journal, 2018, 15(1):116.
    [52] Li P, Wu SQ, Xiao T, Li YL, Su ZM, Wei W, Hao F, Hu GP, Lin FS, Chen XS, Gu ZX, Lin TW, He HY, Li J, Chen SH. Design, synthesis, and evaluation of a novel macrocyclic anti-EV71 agent. Bioorganic& Medicinal Chemistry, 2020, 28(12):115551.
    [53] Li C, Qiao Q, Hao SB, Dong Z, Zhao L, Ji J, Wang ZY, Wen HL. Nonstructural protein 2A modulates replication and virulence of enterovirus 71. Virus Research, 2018, 244:262-269.
    [54] Bai JJ, Chen XX, Liu QQ, Zhou X, Long JE. Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis. Virus Research, 2019, 265:104-114.
    [55] Yao M, Dong YC, Wang Y, Liu H, Ma HW, Zhang H, Zhang L, Cheng LF, Lv X, Xu ZK, Zhang FL, Lei YF, Ye W. N6-methyladenosine modifications enhance enterovirus 71 ORF translation through METTL3 cytoplasmic distribution. Biochemical and Biophysical Research Communications, 2020, 527(1):297-304.
    [56] Yao CG, Hu KH, Xi CL, Li N, Wei YH. Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene. Genes& Genomics, 2019, 41(3):343-357.
    [57] Yang XD, Hu ZL, Fan SS, Zhang Q, Zhong Y, Guo D, Qin YL, Chen MZ. Picornavirus 2A protease regulates stress granule formation to facilitate viral translation. PLoS Pathogens, 2018, 14(2):e1006901.
    [58] Falah N, Montserret R, Lelogeais V, Schuffenecker I, Lina B, Cortay JC, Violot S. Blocking human enterovirus 71 replication by targeting viral 2A protease. Journal of Antimicrobial Chemotherapy, 2012, 67(12):2865-2869.
    [59] 徐骁,姚云芳,李靖,柴克莉,乔文涛,谈娟.肠道病毒71型3D聚合酶转录激活域的界定.病毒学报, 2016, 32(5):560-565. Xu X, Yao YF, Li J, Chai KL, Qiao WT, Tan J. Identification of the transcriptional activity domain of EV713Dpol. Chinese Journal of Virology, 2016, 32(5):560-565.(in Chinese)
    [60] Shi W, Ye HQ, Deng CL, Li R, Zhang B, Gong P. A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Research, 2019, 48(3):1392-1405.
    [61] Kuo RL, Chen CJ, Wang RYL, Huang HI, Lin YH, Tam EH, Tu WJ, Wu SG, Shih SR. Role of enteroviral RNA-dependent RNA polymerase in regulation of MDA5-mediated beta interferon activation. Journal of Virology, 2019, 93(10):e0013219.
    [62] Li YM, Yu J, Qi XW, Yan HM. Monoclonal antibody against EV713Dpol inhibits the polymerase activity of RdRp and virus replication. BMC Immunology, 2019, 20(1):6.
    [63] Wang HQ, Zhong M, Li YP, Li K, Wu S, Guo TT, Cen S, Jiang JD, Li ZR, Li YH. APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity. Antiviral Research, 2019, 165:23-33.
    [64] Hung HC, Chen TC, Fang MY, Yen KJ, Shih SR, Hsu JTA, Tseng CP. Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid. Journal of Antimicrobial Chemotherapy, 2010, 65(4):676-683.
    [65] Xu N, Yang J, Zheng BS, Zhang Y, Cao YM, Huan C, Wang SQ, Chang JB, Zhang WY. The pyrimidine analog FNC potently inhibits the replication of multiple enteroviruses. Journal of Virology, 2020, 94(9):e0020420.
    [66] Sun HY, Gao M, Cui DW. Molecular characteristics of the VP1 region of enterovirus 71 strains in China. Gut Pathogens, 2020, 12:38.
    [67] Wang N, Yang XF, Sun JD, Sun ZX, Ma QY, Wang ZX, Chen ZQ, Wang ZB, Hu F, Wang HJ, Zhou LF, Zhang MS, Xu J. Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection. Cell Death Discovery, 2019, 5:111.
    [68] Liu ZW, Zhuang ZC, Chen R, Wang XR, Zhang HL, Li SH, Wang ZY, Wen HL. Enterovirus 71 VP1 protein regulates viral replication in SH-SY5Y cells via the mTOR autophagy signaling pathway. Viruses, 2019, 12(1):11.
    [69] Ku ZQ, Ye XH, Shi JP, Wang XL, Liu QW, Huang Z. Single neutralizing monoclonal antibodies targeting the VP1 GH loop of enterovirus 71 inhibit both virus attachment and internalization during viral entry. Journal of Virology, 2015, 89(23):12084-12095.
    [70] Rattanapisit K, Chao Z, Siriwattananon K, Huang Z, Phoolcharoen W. Plant-produced anti-enterovirus 71(EV71) monoclonal antibody efficiently protects mice against EV71 infection. Plants:Basel, Switzerland, 2019, 8(12):560.
    [71] Zhao ZL, Li ZL, Huan C, Liu X, Zhang WY. SAMHD1 inhibits multiple enteroviruses by interfering with the interaction between VP1 and VP2 proteins. Journal of Virology, 2021, 95(13):e0062021.
    [72] Swain SP, Mohanty S. Imidazolidinones and imidazolidine-2,4-diones as antiviral agents. ChemMedChem, 2019, 14(3):291-302.
    [73] Meng T, Jia Q, Wong SM, Chua KB. In vitro and in vivo inhibition of the infectivity of human enterovirus 71 by a sulfonated food azo dye, brilliant black BN. Journal of Virology, 2019, 93(17):e0006119.
    [74] 吴振起,刘光华,闫丽娟,南春红,岳志军,王雪峰.正交设计银翘散抗流感病毒作用的实验研究.中华实验和临床病毒学杂志, 2010, 24(6):427-429. Wu ZQ, Liu GH, Yan LJ, Nan CH, Yue ZJ, Wang XF. Experimental study on anti-influenza virus infection with Yinqiao-decoction by orthogonal design. Chinese Journal of Experimental and Clinical Virology, 2010, 24(6):427-429.(in Chinese)
    [75] Chen SG, Cheng ML, Chen KH, Horng JT, Liu CC, Wang SM, Sakurai H, Leu YL, Wang SD, Ho HY. Antiviral activities of Schizonepeta tenuifolia Briq. against enterovirus 71in vitro and in vivo. Scientific Reports, 2017, 7:935.
    [76] Chen SG, Leu YL, Cheng ML, Ting SC, Liu CC, Wang SD, Yang CH, Hung CY, Sakurai H, Chen KH, Ho HY. Anti-enterovirus 71 activities of Melissa officinalis extract and its biologically active constituent rosmarinic acid. Scientific Reports, 2017, 7:12264.
    [77] Ho HY, Cheng ML, Weng SF, Leu YL, Chiu DTY. Antiviral effect of epigallocatechin gallate on enterovirus 71. Journal of Agricultural and Food Chemistry, 2009, 57(14):6140-6147.
    [78] Van Kuppeveld FJ, Hoenderop JG, Smeets RL, Willems PH, Dijkman HB, Galama JM, Melchers WJ. Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. The EMBO Journal, 1997, 16(12):3519-3532.
    [79] Xie SQ, Wang K, Yu WJ, Lu W, Xu K, Wang JW, Ye B, Schwarz W, Jin Q, Sun B. DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71. Cell Research, 2011, 21(8):1271-1275.
    [80] Peng HJ, Shi M, Zhang L, Li YY, Sun J, Zhang LR, Wang XH, Xu XP, Zhang XL, Mao YJ, Ji Y, Jiang JT, Shi WF. Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells. BMC Microbiology, 2014, 14:147.
    [81] Zhang Z, Wang BS, Wu SP, Wen YB, Wang XY, Song XH, Zhang JL, Hou LH, Chen W. PD169316, a specific p38 inhibitor, shows antiviral activity against enterovirus 71. Virology, 2017, 508:150-158.
    [82] Yu J, Dai Y, Fu YX, Wang KZ, Yang Y, Li M, Xu W, Wei L. Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding. Antiviral Research, 2021, 187:105021.
    [83] Fu YX, Zhang L, Zhang F, Tang T, Zhou Q, Feng CH, Jin Y, Wu ZW. Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. PLoS Pathogens, 2017, 13(9):e1006611.
    [84] Li B, Zheng JQ. MicroR-9-5p suppresses EV71 replication through targeting NF-κB of the RIG-I-mediated innate immune response. FEBS Open Bio, 2018, 8(9):1457-1470.
    [85] Wang Y, Zhang ST, Song WJ, Zhang WX, Li JS, Li CX, Qiu YY, Fang YC, Jiang Q, Li X, Yan B. Exosomes from EV71-infected oral epithelial cells can transfer miR-30a to promote EV71 infection. Oral Diseases, 2020, 26(4):778-788.
    [86] Fu YX, Zhang L, Zhang R, Xu SJ, Wang HR, Jin Y, Wu ZW. Enterovirus 71 suppresses miR-17-92 cluster through up-regulating methylation of the miRNA promoter. Frontiers in Microbiology, 2019, 10:625.
    [87] Zhao Q, Xiong Y, Xu JR, Chen S, Li P, Huang Y, Wang YY, Chen WX, Wang B. Host microRNA hsa-miR-494-3p promotes EV71 replication by directly targeting PTEN. Frontiers in Cellular and Infection Microbiology, 2018, 8:278.
    [88] Wang RYL, Weng KF, Huang YC, Chen CJ. Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections. Scientific Reports, 2016, 6:24149.
    [89] Zhang LL, Chen X, Shi YY, Zhou BF, Du C, Liu YJ, Han S, Yin J, Peng BW, He XH, Liu WH. miR-27a suppresses EV71 replication by directly targeting EGFR. Virus Genes, 2014, 49(3):373-382.
    [90] Huang BZ, Chen HP, Zheng YB. MiR-103/miR-107 inhibits enterovirus 71 replication and facilitates type I interferon response by regulating SOCS/STAT3 pathway. Biotechnology Letters, 2021, 43(7):1357-1369.
    [91] Zhang WJ, Huang ZG, Huang MY, Zeng JC. Predicting severe enterovirus 71-infected hand, foot, and mouth disease:cytokines and chemokines. Mediators of Inflammation, 2020, 2020:9273241.
    [92] Liu ML, Lee YP, Wang YF, Lei HY, Liu CC, Wang SM, Su IJ, Wang JR, Yeh TM, Chen SH, Yu CK. Type I interferons protect mice against enterovirus 71 infection. Journal of General Virology, 2005, 86(12):3263-3269.
    [93] Su R, Shereen MA, Zeng XF, Liang YC, Li W, Ruan ZH, Li YK, Liu WY, Liu YL, Wu KL, Luo Z, Wu JG. The TLR3/IRF1/type III IFN axis facilitates antiviral responses against enterovirus infections in the intestine. mBio, 2020, 11(6):e0254020.
    [94] Zhong T, Zhang LY, Wang ZY, Wang Y, Song FM, Zhang YH, Yu JH. Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment. Acta Pharmacologica Sinica, 2017, 38(3):392-401.
    [95] Shih SR, Tsai KN, Li YS, Chueh CC, Chan EC. Inhibition of enterovirus 71-induced apoptosis by allophycocyanin isolated from a blue-green alga Spirulina platensis. Journal of Medical Virology, 2003, 70(1):119-125.
    [96] Huang HI, Chio CC, Lin JY. Inhibition of EV71 by curcumin in intestinal epithelial cells. PLoS One, 2018, 13(1):e0191617.
    [97] Kang NX, Gao HW, He L, Liu YL, Fan HD, Xu QM, Yang SL. Ginsenoside Rb1 is an immune-stimulatory agent with antiviral activity against enterovirus 71. Journal of Ethnopharmacology, 2021, 266:113401.
    [98] Wang SY, Wang W, Hao C, Yu YJ, Qin L, He MJ, Mao WJ. Antiviral activity against Enterovirus 71 of sulfated rhamnan isolated from the green alga Monostroma latissimum. Carbohydrate Polymers, 2018, 200:43-53.
    [99] Feng QY, Zhou HT, Zhang XY, Liu X, Wang J, Zhang CP, Ma XJ, Quan CJ, Zheng ZL. Acarbose, as a potential drug, effectively blocked the dynamic metastasis of EV71 from the intestine to the whole body. Infection, Genetics and Evolution, 2020, 81:104210.
    [100] Gao J, Tang FY, Wang ZG, Yu J, Hu R, Liu L, Kang GD. Post-marketing safety surveillance for inactivated enterovirus 71 vaccines in Jiangsu, China from 2017 to 2019. Vaccine, 2021, 39(9):1415-1419.
    [101] Mao QY, Wang YP, Bian LL, Xu M, Liang ZL. EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD). Expert Review of Vaccines, 2016, 15(5):599-606.
    [102] Du ZC, Huang Y, Bloom MS, Zhang ZB, Yang ZC, Lu JY, Xu JX, Hao YT. Assessing the vaccine effectiveness for hand, foot, and mouth disease in Guangzhou, China:a time-series analysis. Human Vaccines& Immunotherapeutics, 2021, 17(1):217-223.
    [103] Li J, Yin XZ, Lin AW, Nie XZ, Liu LY, Liu SH, Li N, Wang P, Song SS, Wang SN, Xu DY. EV71 vaccination impact on the incidence of encephalitis in patients with hand, foot and mouth disease. Human Vaccines& Immunotherapeutics, 2021, 17(7):2097-2100.
    [104] Li ZQ, Qin ZQ, Tan HF, Zhang CH, Xu JX, Chen J, Ni LH, Yun XX, Cui M, Huang Y, Wang W, Zhang ZB. Analysis of the coverage of inactivated enterovirus 71(EV71) vaccine and adverse events following immunization with the EV71 vaccine among children from 2016 to 2019 in Guangzhou. Expert Review of Vaccines, 2021, 20(7):907-918.
    [105] Wang SY, Zeng J, Zhang XP, Gan ZK, Fan JQ, Chen YP, Liang ZZ, Hu XS, Zeng G, Lv HK. Short-term dynamic changes in neutralizing antibodies against enterovirus 71 after vaccination. Human Vaccines& Immunotherapeutics, 2020, 16(7):1595-1601.
    [106] Fan ST, Liao Y, Jiang GR, Wang LC, Zhao H, Yu L, Xu XL, Li DD, Zhang Y, Li QH. Efficacy of an inactivated bivalent vaccine for enterovirus 71 and coxsackievirus A16 in mice immunized intradermally. Vaccine, 2021, 39(3):596-604.
    [107] Yang T, Liu BF, Yue L, Xie TH, Li H, Shao MX, Yang R, Luo FY, Long RX, Xie ZP. Preclinical safety assessment of a combined vaccine against hepatitis A virus and enterovirus 71. Vaccine, 2021, 39(29):3952-3963.
    [108] Wang ZY, Zhou CL, Gao F, Zhu QJ, Jiang YX, Ma XX, Hu YL, Shi LK, Wang XL, Zhang C, Liu BF, Shen LZ, Mao QY, Liu G. Preclinical evaluation of recombinant HFMD vaccine based on enterovirus 71(EV71) virus-like particles (VLP):immunogenicity, efficacy and toxicology. Vaccine, 2021, 39(31):4296-4305.
    [109] Kim HJ, Son HS, Lee SW, Yoon Y, Hyeon JY, Chung GT, Lee JW, Yoo JS. Efficient expression of enterovirus 71 based on virus-like particles vaccine. PLoS One, 2019, 14(3):e0210477.
    [110] Wang X, Dong K, Long M, Lin F, Gao ZW, Wang L, Zhang Z, Chen X, Dai Y, Wang HP, Zhang HZ. Induction of a high-titered antibody response using HIV gag-EV71 VP1-based virus-like particles with the capacity to protect newborn mice challenged with a lethal dose of Enterovirus 71. Archives of Virology, 2018, 163(7):1851-1861.
    [111] Luo J, Huo CL, Qin H, Hu JH, Lei L, Pan ZS. Chimeric enterovirus 71 virus-like particle displaying conserved coxsackievirus A16 epitopes elicits potent immune responses and protects mice against lethal EV71 and CA16 infection. Vaccine, 2021, 39(30):4135-4143.
    [112] Yang ZJ, Gao F, Wang XL, Shi LK, Zhou Z, Jiang YX, Ma XX, Zhang C, Zhou CL, Zeng XF, Liu G, Fan J, Mao QY, Shi L. Development and characterization of an enterovirus 71(EV71) virus-like particles (VLPs) vaccine produced in Pichia pastoris. Human Vaccines& Immunotherapeutics, 2020, 16(7):1602-1610.
    [113] Lei L, Li Q, Xu SH, Tian MY, Zheng XH, Bi YX, Huang B. Transplantation of enterovirus 71 virion protein particle vaccine protects against enterovirus 71 infection in a neonatal mouse model. Annals of Transplantation, 2021, 26:e924461.
    [114] Liu JN, Zhao BB, Xue L, Wu J, Xu YF, Liu YD, Qin C. Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections. Virology Journal, 2020, 17(1):58.
    [115] Kim YG, Lee YS, Jung JW, Jin HE. Epitope peptide amphiphile-based nanofiber as an effective vaccine for viral infectious diseases. Journal of Nanoscience and Nanotechnology, 2020, 20(9):5329-5332.
    [116] Wang YY, Meng FY, Li JX, Li GF, Hu JL, Cao JQ, Yu QF, Liang Q, Zhu FC. Willingness of parents to vaccinate their 6-60-month-old children with EV71 vaccines:a cross-sectional study in rural areas of northern Jiangsu province. Human Vaccines& Immunotherapeutics, 2020, 16(7):1579-1585.
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ZHANG Xiangfei, LIU Chang, HU Bing, WANG Ruijuan, QIN Jianru, WANG Jianhua. Research progress of drugs and vaccines against enterovirus 71. [J]. Acta Microbiologica Sinica, 2022, 62(4): 1216-1230

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  • Received:August 02,2021
  • Revised:September 07,2021
  • Online: April 15,2022
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