Global regulatory protein DasR in Streptomyces

Abstract:

Streptomycetes produce a variety of secondary metabolites,which are highly valuable in clinical practice,agriculture,animal husbandry,biotechnology,etc.The research on the regulatory networks of secondary metabolites in Streptomycetes will improve their yields and facilitate the discovery of novel secondary metabolites.The biosynthesis of secondary metabolites in Streptomycetes can be regulated in a global or pathway-specific manner.The global regulators can target multiple pathway-specific genes and biosynthesis genes,playing a universal and complicated role.Therefore,studying the global regulation will improve the understanding of the complicated regulation networks in Streptomycetes.DasR,a global regulator,plays a key role in the nutrient sensing,morphological changing,and secondary metabolism.In this review,we summarized the structure,sequence,and function of DasR,and reviewed the research findings on role of DasR in the growth,secondary metabolism,nutrient sensing,and primary metabolism of Streptomycetes.

Key words:DasR;Streptomyces;global regulation;secondary metabolism;nutrient sensing