Inflammatory responses to viral infections: a double-edged sword in the antiviral defense of host

Abstract:

Innate immune response serves as the first line and the most rapid system of host defense against the invasion of microbial pathogens. Pattern recognition receptors in the host innate immune system activate a number of proinflammatory cytokines and cause inflammatory response after recognizing the invasion signal. Viral infections may activate immune responses of host. The strong regulatory network of inflammatory response plays a key role in the antiviral process of host to maintain the homeostasis. This paper reviews the inflammatory response induced by viral infections, focusing on the host regulatory network of inflammatory response, and the mechanisms of DNA and RNA viruses in regulating inflammatory response, aiming to provide some references for the treatment of immune diseases caused by viral infections.

Key words:inflammatory response;viral infection;immunomodulatory mechanism;pathological damage