Role of inflammasome in blood-brain barrier injury: a review

doi:10.13343/j.cnki.wsxb.20220255

Home > Archive>Volume 62, Issue 12, 2022 >4798-4810. DOI:10.13343/j.cnki.wsxb.20220255

Role of inflammasome in blood-brain barrier injury: a review
DOI:
                        10.13343/j.cnki.wsxb.20220255
                    
CSTR:
                        32112.14.j.AMS.20220255
                    
Author:
                        JIA KaixiangJIA Kaixiang
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China
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CAO XinruiCAO Xinrui
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China
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FANG RendongFANG Rendong
Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China;Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China
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Abstract:

Blood-brain barrier (BBB) is a natural structural and functional barrier, which can inhibit the entry of pathogens and control the entry of molecules into the brain parenchyma. An intact BBB is essential to maintain the homeostasis of the central nervous system. The function of this barrier is determined by its special multicellular structure. Each cell type has an indispensable contribution to the BBB integrity. Inflammasome known as a complex protein is a key component of the innate immune system and mediates the secretion of pro-inflammatory cytokines including IL-1β, IL-18, and IL-1α, which plays a critical role in the excessive inflammatory response. The up-regulated expression of proinflammatory cytokines results in the destruction of BBB. As a result, the pathogen breaks through BBB and enters the central nervous system, which finally causes brain diseases. In this paper, we reviewed infectious diseases and non-infectious diseases associated with the inflammasome-mediated injury of BBB.

Key words:blood-brain barrier;inflammasome;innate immunity

Reference

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JIA Kaixiang, CAO Xinrui, FANG Rendong. Role of inflammasome in blood-brain barrier injury: a review. [J]. Acta Microbiologica Sinica, 2022, 62(12): 4798-4810

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Received:April 04,2022
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