Potential and mechanism of Akkermansia muciniphila in disease treatment

Abstract:

Akkermansia muciniphila (AKK) promotes the secretion, maintains the dynamic balance, and regulates the barrier function of intestinal mucus, playing a key role in metabolic regulation and immune response. As a promising next-generation probiotic, AKK can mitigate diseases such as intestinal inflammation, metabolic disorders, neuroinflammation, and cancers. We introduced the therapeutic potential of AKK for diseases of the digestive system, the nervous system, metabolic disorders and cancers, aiming to provide a systematic review of the potential role and molecular mechanism of AKK in disease treatment.