Progress in probiotics for Parkinson's disease

Abstract:

Parkinson's disease is a common neurodegenerative disease with the cause remaining unknown. The available therapies are characterized by high costs, limited efficacy, and strong side effects. Gastrointestinal dysfunction is common in the patients with Parkinson's disease. Studies have demonstrated the association between Parkinson's disease and intestinal flora, and the patients are expected to be treated by probiotics which can restore the intestinal flora. The engineering of probiotics makes it feasible to modify probiotics according to people's wishes and improve their stability and targeting, thus giving full play to the role of probiotics in disease treatment. We reviewed the relevant studies in recent years, elaborated on the possible treatment mechanisms, and further analyzed the feasibility of engineering probiotics in the treatment of Parkinson's disease, aiming provide new ideas for the safe treatment of this disease.

Key words:Parkinson's disease;intestinal flora;gut-brain axis;probiotic therapy