Akkermansia muciniphila in adjuvant treatment of malignant tumors

Abstract:

Malignant tumors are a major global public health problem threatening human health. The combination of multiple therapies, especially targeted therapy combined with immunotherapy, can slow down the progress of malignant tumors and improve the short-term survival rate of the patients. However, these treatment methods cannot cover all patients and have limited long-term efficacy. Therefore, how to improve the quality of life and long-term survival rate and reduce mortality of the patients has become a key problem to be solved. Increasing studies have demonstrated that the distribution of intestinal microorganisms is associated with the occurrence and development of malignant tumors, and regulating intestinal microbiota can serve as a new adjuvant therapy for malignant tumors. Despite the extensive studies about Akkermansia muciniphila in tumor treatment, little is known about the safety and effectiveness of A. muciniphila in the adjuvant treatment of malignant tumors. Therefore, we summarized the research results and application results of A. muciniphila by reviewing the studies on malignant tumors in recent years, aiming to enrich the choices for the comprehensive treatment in clinical practice.

Key words:Akkermansia muciniphila;intestinal microbiota;malignant tumors;adjuvant treatment