Role of LPXTG-anchored protein Lmo0880 in Listeria monocytogenes infection
Author:
  • LIN Kechen

    LIN Kechen

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • LI Haojie

    LI Haojie

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • ZHAO Xiuling

    ZHAO Xiuling

    Technical Center of Ningbo Customs, Ningbo Academy of Quarantine & Inspection Science and Technology, Ningbo 315000, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • ZHOU Si

    ZHOU Si

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • LIAO Junhui

    LIAO Junhui

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • WANG Zinian

    WANG Zinian

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • JIN Gexuan

    JIN Gexuan

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • ZHU Fuxin

    ZHU Fuxin

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • XU Jiali

    XU Jiali

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • SUN Jing

    SUN Jing

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • SONG Houhui

    SONG Houhui

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • DENG Simin

    DENG Simin

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • CHENG Changyong

    CHENG Changyong

    Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Research Center for Animal Health Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China
    Find this author on All Journals
    Find this author on BaiDu
    Search for this author on this site
  • Article
  • | |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    【Objective】 To generate Listeria monocytogenes strains with lmo0880 deleted and complemented strains, so as to investigate the roles of Lmo0880 in bacterial infection in a host. 【Methods】 The lmo0880-deleted strain was generated by homologous recombination, and the complementary strain was constructed by introducing an integrative plasmid carrying lmo0880 into the lmo0880-deleted strain. The growth, adhesion, invasion, and intracellular proliferation were compared between the lmo0880-deleted strain, complementary strain, and the wild type. 【Results】 The deletion of lmo0880 did not significantly impact bacterial growth or adhesion. However, it led to notable decreases in cell invasion, proliferation, and colonization in the liver and spleen, ultimately diminishing the pathogenicity in mice. 【Conclusion】 The LPXTG-anchored protein Lmo0880 plays a crucial role in bacterial invasion, proliferation, and colonization in a host. These findings provide a solid foundation for deeply understanding the pathogen-host interaction during L. monocytogenes infection.

    Reference
    Related
    Cited by
Get Citation

LIN Kechen, LI Haojie, ZHAO Xiuling, ZHOU Si, LIAO Junhui, WANG Zinian, JIN Gexuan, ZHU Fuxin, XU Jiali, SUN Jing, SONG Houhui, DENG Simin, CHENG Changyong. Role of LPXTG-anchored protein Lmo0880 in Listeria monocytogenes infection. [J]. Acta Microbiologica Sinica, 2024, 64(3): 893-906

Copy
Related Videos

Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:September 21,2023
  • Revised:December 15,2023
  • Online: March 18,2024
  • Published: March 04,2024
Article QR Code