Research progress in the relationship between gut microbiota and Parkinson's disease

doi:10.13343/j.cnki.wsxb.20240209

Home > Archive>Volume 64, Issue 10, 2024 >3610-3619. DOI:10.13343/j.cnki.wsxb.20240209

Research progress in the relationship between gut microbiota and Parkinson's disease
DOI:
                        10.13343/j.cnki.wsxb.20240209
                    
CSTR:
                        32112.14.j.AMS.20240209
                    
Author:
                        WANG YujingWANG Yujing
School of Public Health, Shandong Second Medical University, Weifang 261053, Shandong, China;School of Public Health, Jining Medical University, Jining 272067, Shandong, China
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XIE RuiningXIE Ruining
School of Public Health, Jining Medical University, Jining 272067, Shandong, China
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JIA ShuangshuangJIA Shuangshuang
School of Public Health, Jining Medical University, Jining 272067, Shandong, China
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LI YaqingLI Yaqing
School of Public Health, Shandong Second Medical University, Weifang 261053, Shandong, China;School of Public Health, Jining Medical University, Jining 272067, Shandong, China
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QIAO YiQIAO Yi
School of Public Health, Jining Medical University, Jining 272067, Shandong, China
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Abstract:

Parkinson's disease is a common neurodegenerative disorder that seriously threatens the health of middle-aged and elderly individuals.However,the pathogenesis of Parkinson's disease is not fully understood.Recent studies have shown that gut microbiota plays an important role in the occurrence and development of Parkinson's disease.Gut microbiota and its metabolites influence the intestinal mucosal barrier,neuroinflammation,endocrine system,and other aspects through the microbiota-gut-brain axis,thereby participating in the occurrence and development of Parkinson's disease.Gut microbiota can be regulated by various methods such as probiotic supplementation,fecal microbiota transplantation,dietary adjustments,and traditional Chinese medicine interventions,being an important target for the prevention and treatment of Parkinson's disease.This article reviews the possible mechanisms of gut microbiota being involved in the occurrence of Parkinson's disease and further discusses the current status of prevention and treatment of gut microbiota dysbiosis.

Key words:Parkinson?'s disease;gut microbiota;metabolites of gut microbiota

Reference

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WANG Yujing, XIE Ruining, JIA Shuangshuang, LI Yaqing, QIAO Yi. Research progress in the relationship between gut microbiota and Parkinson's disease. [J]. Acta Microbiologica Sinica, 2024, 64(10): 3610-3619

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Received:March 30,2024
Revised:May 21,2024
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Online: September 30,2024
Published: October 04,2024

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