Research progress on the mechanism of intracellular-induced expression of antimicrobial peptide LL-37

Abstract:

Innate immunity constitutes the first line of immune defense.As a part of the body?'s innate immunity,the antimicrobial peptide LL-37 plays a crucial role in maintaining homeostasis,with two primary functions:direct antimicrobial activity and immunomodulation.Currently,research on LL-37 mainly focuses on its function,while its induced expression in vivo has rarely been studied.However,understanding the induced expression of LL-37 is essential for delving into the body?'s immune defense mechanisms.Therefore,this paper briefly reviewed the research progress on the synthesis and functions of LL-37,the factors inducing its secretion,and the regulatory pathways involved in its induced expression.The aim is to offer new insights into the regulatory pathways and immune defense functions of LL-37 in the human body.

Key words:antimicrobial peptide LL-37;in vivo induction;regulatory pathways