Research progress of cAMP signaling pathway in phytopathogenic fungi

Abstract:

Cyclic adenosine monophosphate (cAMP) is a second messenger widely present in eukaryotes. It is synthesized by adenylate cyclase (AC) and regulates downstream protein activity by binding to protein kinase A, thereby regulating fungal growth and development, virulence, cell wall integrity, environmental stress responses, and sexual/asexual reproduction. This article introduces the research progress of the cAMP signaling pathway in phytopathogenic fungi and the cooperation of this pathway with other signaling pathways in regulating cellular processes. At the same time, it elucidates the role of the cAMP signaling pathway in the infection of plant phytopathogenic fungi. This review is expected to provide reference for screening the agents for inhibiting phytopathogenic fungi that target the genes or proteins in the cAMP pathway. Additionally, the cAMP signaling pathway could be targeted to prevent and control the growth, development, and pathogenicity of phytopathogenic fungi in the future.