Polyketide antibiotics produced by polyketide synthase in streptomyces-A review

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Polyketide antibiotics produced by polyketide synthase in streptomyces-A review
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                        Minjie ChenMinjie Chen
South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China
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Guanghua WangGuanghua Wang
South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China
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Shikun DaiShikun Dai
South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China
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Lianwu XieLianwu Xie
South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China
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Xiang LiXiang Li
South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China
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Fund Project:Supported by the Project of Knowledge Innovation of Chinese Academy of Sciences (07YZ075001，07YZ073001）

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Abstract:

Abstract: Polyketides have played an important role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. Furthermore, the biosynthetic gene clusters for numerous bioactive polyketides have been intensively studied over the past 15 years. This paper focuses on the polyketide drugs approved by US-FDA and takes a general view in the antibiotics produced by polyketide synthase in streptomyces.

Key words:Keywords: streptomyces; polyketide antibiotics; polyketide synthase

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Minjie Chen, Guanghua Wang, Shikun Dai, Lianwu Xie, Xiang Li. Polyketide antibiotics produced by polyketide synthase in streptomyces-A review. [J]. Acta Microbiologica Sinica, 2009, 49(12): 1555-1563

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Received:May 15,2009
Revised:June 01,2009
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