Recent advance and prospect on taxol production by endophytic fungus fermentation – A Review

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Recent advance and prospect on taxol production by endophytic fungus fermentation – A Review
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Fund Project:Supported by the National Science Foundation of China (30570025), the Fifteen Important Items of Heilongjiang(GA02C101), the Research Program for Scholars Overseas by Heilongjiang Education Bureau (1152HZ06), the Harbin Youth Science Foundation(2005AFQXJ0

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Abstract:

Taxol has become a widely used clinical anti-cancer drug. Due to the scaricity of Taxus trees, current taxol output cannot meet the requirement of the market. Taxol produced by endophytic fungus fermentation has high prospective. We reviewed advantages of taxol production by fungus fermentation, research advances of isolation, biodiversity of taxol-producing fungi and methods of improved taxol output by endophytic fungus fermentation.

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Kai Zhao, Wenxiang Ping, Dongpo Zhou. Recent advance and prospect on taxol production by endophytic fungus fermentation – A Review. [J]. Acta Microbiologica Sinica, 2008, 48(3): 403-407

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