Retinoic acid-inducible gene-I-like receptors and RNA virusrecognition—— A review
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Supported by the National Natural Science Foundation of China (30570084, 30600530) and the Key Project of China National Programs for Fundamental Research and Development (2002CB513205)

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    Abstract:

    Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) have recently been identified as cytoplasmic sensors for RNA viruses. The RLR signaling cascades induce the production of type I interferons and pro-inflammatory cytokines, which are rigorously regulated by the host. On other side, RNA viruses have evolved strategies to evade RLR signaling. In this review, we present our current understanding of RLR signaling in RNA virus recognition and antiviral innate immunity.

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Chengfeng Qin, Ede Qin. Retinoic acid-inducible gene-I-like receptors and RNA virusrecognition—— A review. [J]. Acta Microbiologica Sinica, 2008, 48(10): 1418-1423

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