动物胚胎植入与子宫内膜类器官研究进展

Research progress in animal embryo implantation and endometrial organoids

摘要:

胚胎植入涉及胚胎与母体子宫内膜间复杂的相互作用，目前对于胚胎植入仍然有许多问题有待探究。子宫内膜上皮类器官与子宫内膜组装体模型为体外研究胚胎植入的过程提供了一个全新的思路。本文总结了胚胎植入过程、雌孕激素协同、胚胎源信号对子宫内膜容受态建立的调控机制、子宫内膜类器官的建立、子宫内膜组装体以及利用内膜组装体探索母-胎互作的最新研究进展，为研究胚胎植入过程中胚胎与母体子宫间的交流互作提供了新策略。

关键词:胚胎植入;子宫内膜;子宫内膜类器官;子宫内膜组装体

Abstract:

Embryo implantation involves a complex interaction between the embryo and the endometrium of the mother, the study of which faces a variety of problems. The modeling of endometrial epithelial organoids and endometrial assembloids provides a new way to study the process of embryo implantation in vitro. This paper summarized the latest research progress in embryo implantation, the regulation mechanism of endometrial receptivity by estrogen- progesterone coordination and embryo-derived signals, the establishment of endometrial organoids, and the development and application of endometrial assembloids in the research on mother-embryo interaction, providing new strategies for studying the communication between embryo and maternal uterus during implantation.

Key words:embryo implantation;endometrium;endometrial organoids;endometrial assembloids