腺苷酸活化蛋白激酶在糖脂代谢调控中的研究进展

Research progress of Adenosine 5ʹ-monophosphate-activated protein kinase in the regulation of glycolipid metabolism

摘要:

AMP激活的蛋白激酶 (AMP-activated protein kinase，AMPK) 是一种异源三聚体复合物，作为机体能量平衡和糖脂代谢的重要激酶参与多种生理过程的调节。研究表明，炎症、糖尿病和癌症等多种慢性疾病也与AMPK功能和活性调节有密切关系。新近发现，糖尿病一线用药二甲双胍抑制肝糖产生改善病人高血糖的作用与AMPK激活有关，提示靶向AMPK可能是预防和治疗多种慢性疾病的有效策略之一。文中从AMPK的结构与活性、AMPK在糖代谢调控中的作用和AMPK在血脂代谢调控中的作用3个方面综述了AMPK研究的进展，旨在为糖脂代谢调控的基础和临床研究提供依据。

关键词:AMP激活的蛋白激酶，糖尿病，糖代谢，脂代谢

Abstract:

Adenosine 5?-monophosphate-activated protein activated protein kinase (AMPK), a heterotrimeric complex, is an important kinase to regulate glycolipid metabolism and energy balance involved in a variety physiological processes in human body. Many research indicated that the function and activity of AMPK were closely related to inflammation, diabetes and cancers. Recent reports show that inhibition of metformin (a first-line drug) on hepatic glucose in patients with hyperglycemia is associated with AMPK pathway, suggesting that targeting AMPK may be one of the effective strategies for the prevention and treatment of a variety of chronic diseases. Here, we review research progress on the structure, activation and regulation of AMPK in glycolipid metabolism to provide an insight into the basic and clinical research of diabetes therapy.

Key words:AMP-activated protein kinase, diabetes, glucose metabolism, lipid metabolism