基于环状RNA开发核酸药物研究进展
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国家自然科学基金(U22A20326)


Research advances in nucleic acid drugs developed based on circular RNAs
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    摘要:

    核酸药物是继化学药物和蛋白质药物之后的第三代药物,其中mRNA疫苗在抗击新型冠状病毒中发挥了重要作用。mRNA疫苗因其开发周期短,制备工艺成熟,在应对病毒变异、支持全球供应上具有显著优势。相比mRNA,环状RNA (circular RNA, circRNA)是一类具有更稳定的结构、更长的半衰期、更弱免疫原性等优点的分子,并且已被证实可以高效表达蛋白产物,由此可见环状RNA药物的开发前景更为广阔。虽然环状RNA的生物学功能有大量研究,但基于环状RNA开发核酸药物的研究还很少。本文概述了环状RNA的基本信息,总结了环状RNA的合成路径及作用机制,并讨论了该领域的发展方向,希望为环状RNA药物的研发提供一些启示和帮助。

    Abstract:

    The development and clinical application of nucleic acid drugs has been a trendy field. One of the notable examples is mRNA vaccines, which have been used in the fighting against SARS-CoV-2. With short development cycles and mature preparation processes, mRNA vaccines demonstrate advantages in the global supply and in response to virus mutations. Circular RNAs (circRNAs) are a group of nucleic acid molecules with more stable structure, longer half-life, and weaker immunogenicity than mRNAs. Studies have proven that circRNAs can efficiently express protein products, indicating their potential in drug development. Despite extensive studies on the biogenesis and biological functions of circRNAs, there is limited research on developing nucleic acid drugs based on circRNAs. This article provides an overview of circRNAs, including their basic information, synthesis routes, and mechanisms, and discusses the future development directions of this field, hoping to provide inspiration for the research and development of drugs based on circRNAs.

    参考文献
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    [15] LEPPEK K, BYEON GW, KLADWANG W, WAYMENT-STEELE HK, KERR CH, XU AF, KIM DS, TOPKAR VV刬???潏浅瀠慃爬椠獒潏湔?睓楃瑈桉?剄丠慄猬攠???嬠?嵃??呗桅敌??潎畇牔湏慎氭?潇晕??椠潒氬漠杆楕捊慉汉??栬攠浓楈獁瑒牍祁??水?し休??????休?????????????????扎牏?孊水?嵔?兎啇????夬??婉奁??卆??乃?奉????乥??剡?????乭????塴啯?奩奡??坯啰?婩???呡?乩???塯??婭??乁??塴塲??呴??乥????坡?乩??????塡??传?塲???佬乡??塯????啲传?????啡?卥奤??奨?乲???奵??呣?乛?????奡?乵??夠??奭啭?坮???坴?乯?????‰攲琲?愠氱???椱爵挳甶氮愼牢?刾乛??癝愠捍捏楏湒故猠?慊本愠楑湕獅瑒?匠?剃匮??潯噩???慧渠摯?攠浒敎牁杳椠湢杹?癳慰牬楩慮湴瑥獤嬠?嵩???敩汯汮????㈠???????ㄠど?????????????攠????戬爠?嬱祝?崠?夰?中?′????婲?啛?????协問乒????????乩?奩奮???啎?夠剭??呥?乵?奥???坩啴??偔??婄?????呧??坥????堠?????乤???啮?乍??????佡啲?兂???呯佧乹??娱???????吸?传??????吼??举????匠啋乒?婇???婋唬传??????湓瑋牉愠瑐畊洬漠牚慁汕?搠敁汊椬瘠敓牁敎摄?渠潊瘬攠汇?捔楔牓捃畈汌慉牎?洠剄久??敃湅捃潈搠楔湒朮?捓祥瑬潦欭楳湰敬獩?晩潮牧?楒济流町渠敡?浴潯摥畸汣慩瑳楩潯湮?慡湮摤?捡慵湴捯散特?瑬桩敺牡慴灩祯孮?嵯???潨汥攠捲畩汢慯牳?呭桡敬爠慒灎祁?乩畮捴汥敲楶捥??据楧搠獳???づ?????て???????????扡牛?孝金?嵃?????唱?券夲????倨?利刺??唴?吭??倷???湲 ̄敛昱昹楝挠楗故湓瑓?獌瑈牏慅瑆敔朠祒?昬漠牋?瑗桁敌?獋祉渠瑐桓攬猠楁獎?潅晒?捏楎爠捄畇氮愠牅?剧乩??浥潲汩敮捧甠汣敩獲季?嵬??丠畒捎汁攠楦捯??捰楯摴獥?剴攠獡敮慤爠捳桴?????????????????ど????に????扴物?嬠??嵬??????吠??坴?卲卥???佭??呮?剣??????丬?刲???丬??刺匠伲丶′???????串???奌???楃牘挬甠汇慕牏?剓之??济楁李爠慆琬椠潘湕?楙湆?愠杙慁牎潇猠敌?朠敃汈?敎氠敌捌琮爠潒灎桁漠牣敩獲楣獬孥?崠???潨氠敭捩畮汩慭物??敤氠汩???の?????????????????????敋???扮牨?孢?ぴ嵯??啛告呝????????啬呡???乥乬?丬?′到?串听???匨吲?刺???‰匭礴渳琴栮敥琶椮挼?浲刾乛??捝愠灑灉楕渠杚嬬?嵈???救椬氠獚瑈敁楏渠??漠畚版湕愠汊?漠晚?佁爠杍愬渠楌捉??栬攠浌楉猠瑙爬礠????????????㈠??????????扇爠?嬬??嵕?圠?匬匠???传??吠?剬????佐坉??匠???偯卶??倠?剴??剴???????????啩?乩??奴塬????卮?剴???乴???丠??剥卣佩乳?????剣乒??挠楷物捴畨氠慴牨楯穲慯瑵楧潨湬?搠業浩楮湩業獩桺敥獤?楩浭浭畵湮潯杧敥湮楩捣楩瑴祹?慴湯搠?捩慲湥?整砠瑰敯湴摥?瑴爠慡湮獤氠慤瑵楲潡湢?摥甠牰慲瑯楴潥湩??楥?楰湲?癳楳癩潯??楅?嬯?嵌???潢汲放捛甲氰愲爳??攱氭氱??㈠と????????????ど????ぶ?攠???戯牣?孮??嵮????丮?刱??圯?丰?′匮???????????????夼????′???婍?????剖??乓?匠?????????呇?????丠?????坏?丠??删?偁??????之???女???湦朠楡湮攠敥牮楧湩杮?捥楲牥捤甠汲慩牢?剺乹??映潴牯?数湲桯慤湵捣敥搠?瀠牣潩瑲散極湬?灲爠潨摵畭捡瑮椠潥湸孯?嵛??丮愠瑎畵牣敬??楣漠瑁散捩桤湳漠汒潥杳祥???と水???????有?㈨?名?呼??戰爸?嬭??崹?娮??乲?????娠??乔???????丬????塵啭????????娮夠????啣???????啩??塴?????塴偲??婥??佥???? 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?????????????????戀爀?嬀??崀?匀吀?刀伀匀吀?一???嘀??匀??刀??刀?一?匀嘀???一吀刀伀倀伀嘀??一??匀吀?倀?一伀嘀?????匀??嘀???嘀??夀?????娀??????刀唀?伀??吀伀嘀??倀???伀刀?伀夀??伀嘀??????刀唀?伀??吀伀嘀??一?????刀???一?伀?嘀夀????一?????一?伀?一嘀????????嘀??一????娀??一?匀?????夀????嘀???????刀倀?一?伀??????漀渀猀琀爀甀挀琀椀漀渀?愀渀搀?椀洀洀甀渀漀最攀渀椀挀椀琀礀?漀昀?洀漀搀椀昀椀攀搀?洀刀一??瘀愀挀挀椀渀攀?瘀愀爀椀愀渀琀猀?攀渀挀漀搀椀渀最?椀渀昀氀甀攀渀稀愀?瘀椀爀甀猀?愀渀琀椀最攀渀猀嬀?崀??嘀愀挀挀椀渀攀猀??? ??????????????
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郭士琳,李常昆,吕得玚,陈骐. 基于环状RNA开发核酸药物研究进展[J]. 生物工程学报, 2024, 40(5): 1421-1430

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  • 收稿日期:2023-11-28
  • 最后修改日期:2024-02-12
  • 在线发布日期: 2024-05-06
  • 出版日期: 2024-05-25
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