脂联素生物传感器的研究进展

Research progress in biosensors for adiponectin

摘要:

脂联素是脂肪组织细胞因子之一，也是一种新定义的脂肪细胞因子，可以参与胰岛素、葡萄糖和脂肪细胞代谢过程。脂联素水平降低会增加发生代谢综合征(metabolic syndrome, MS)的风险。脂联素因其具有抗动脉粥样硬化和有效的胰岛素增敏作用而被认为是治疗2型糖尿病(type 2 diabetes mellitus, T2DM)和MS的重要工具。因此，准确测定人血浆中的脂联素浓度对T2DM和MS的预测及治疗决策具有重要的意义。目前，已经开发了许多生物传感器用于检测脂联素等生物标志物。本文综述了电化学传感器、表面增强拉曼散射传感器以及化学发光微流控传感器在脂联素检测领域中的应用，阐述了近年来脂联素传感器的研究进展，以期为脂联素传感器的进一步研究及其在医疗领域中的应用提供参考。

关键词:脂联素;代谢综合征;电化学;表面增强拉曼散射;微流控;生物传感器

Abstract:

Adiponectin, a cytokine associated with adipose tissue, is a recently defined adipocytokine involved in insulin, glucose, and adipocyte metabolism. Reduced adiponectin levels can increase the risk of developing metabolic syndrome (MS). Adiponectin is considered an important target for the treatment of type 2 diabetes mellitus (T2DM) and MS due to its anti-atherosclerotic and insulin-sensitizing effects. Therefore, the accurate determination of adiponectin concentrations in human plasma is necessary for the management of both T2DM and MS. A variety of biosensors have been developed for the detection of biomarkers such as adiponectin. This paper reviews the applications of electrochemical sensors, surface-enhanced Raman scattering sensors, and microfluidic chip-based chemiluminescence sensors in the detection of adiponectin and the recent research progress in the sensors for the detection of adiponectin, aiming to provide a reference for the research and application of sensors for adiponectin in the medical field.

Key words:adiponectin;metabolic syndrome;electrochemical;surface-enhanced Raman scatting;microfluidic;biosensor