科微学术

生物工程学报

2025年5月11日 10:15 星期日
首页 > 过刊浏览>2024年第40卷第9期 >2968-2982. DOI:10.13345/j.cjb.230807
PDF HTML阅读 XML下载 导出引用 引用提醒
生命领域重大科技基础设施发展特征、问题与对策
作者:
基金项目:

国家自然科学基金(72341005)


Development characteristics, problems and countermeasures of major scientific and technological infrastructures in the field of life sciences
Author:
  • 摘要
    • | |
  • 访问统计
    • |
  • 参考文献 [46]
    • |
  • 相似文献
    • |
  • 引证文献
    • | |
  • 文章评论
    摘要:

    生命科学领域重大科技基础设施是国家重大科技基础设施板块中不可缺少的重要内容，其前沿性、战略性、基础性强，具有与粒子物理、天文、核能源等传统设施领域不同的特点，也是我国设施相对“短板”的领域。研究发现，生命领域设施在资金投入、物理形态、设施寿命、数字化程度、组织形式、项目风险和发展效应等方面，具有与传统设施领域不同的特点。生命领域设施在立项、投入、管理和建设方面还需要强化生命领域大科学问题凝练机制，提升战略性投入布局水平，推进基于原创科学思路的技术设备国产化，加强生命领域设施的差异化管理能力。

    Abstract:

    The major science and technology infrastructure in the field of life science is an indispensable and important content in the large-science facility landscape. It encompasses cutting-edge, strategic, and fundamental aspects. This field differs from traditional facilities such as particle physics, astronomy and nuclear energy. Moreover, it represents a relatively underdeveloped area in China’s facility landscape. Unique characteristics are observed in terms of capital investment, physical form, facility lifespan, digitization degree, organizational structure, project risk, and development effect when compared to traditional facilities. Despite its importance, challenges persist in project establishment, investment, management, and construction. Therefore, it is necessary to strengthen the condensing mechanism for addressing major scientific issues in the life science field, improve the strategic investment layout, facilitate the localization of technical equipment based on original scientific ideas, and strengthen the differentiated management capacity of life science facilities.

    参考文献
    [1] 丁陈君, 陈方, 郑颖, 吴晓燕, 宋琪. 全球生物科技发展态势及对我国的启示[J]. 世界科技研究与发展, 2020, 42(2): 133-143. DING CJ, CHEN F, ZHENG Y, WU XY, SONG Q. The development trend of global biotechnology and its enlightenment to China[J]. World Sci-Tech Research & Development, 2020, 42(2): 133-143(in Chinese).
    [2] 吴家睿. 21世纪生物医学的三个主要发展趋势[J]. 生命科学, 2022, 34(11): 1327-1335. WU JR. Three major trends in biomedicine in the 21st century[J]. Chinese Bulletin of Life Sciences, 2022, 34(11): 1327-1335(in Chinese).
    [3] 刘建安, 于辉, 王秀东. 农业重大科技基础设施建设的实践与思考[J]. 农业科技管理, 2021, 40(1): 48-50, 96. LIU JA, YU H, WANG XD. Practice and thinking on the construction of major agricultural science and technology infrastructure[J]. Management of Agriculture Science and Technology, 2021, 40(1): 48-50, 96(in Chinese).
    [4] 张亭, 冷梦甜, 金帆, 袁海. 合成生物研究重大科技基础设施概述[J]. 合成生物学, 2022(1): 184-194. ZHANG T, LENG MT, JIN F, YUAN H. Overview on platform for synthetic biology research at Shenzhen[J]. Synthetic Biology Journal, 2022(1): 184-194(in Chinese).
    [5] 王畅, 王蒲生. 欧洲转化医学平台对中国医学转化中心建设的启示[J]. 科技管理研究, 2022, 42(4): 60-65. WANG C, WANG PS. Enlightenment of EATRIS on the translational medicine centers construction in China[J]. Science and Technology Management Research, 2022, 42(4): 60-65(in Chinese).
    [6] 刘霞.美国2023财年预算大幅增加科研支出[N].科技日报, 2022-03-31. Liu X. The U.S. budget for fiscal year 2023 significantly increases spending on scientific research[N]. Science and Technology Daily, 2022-03-31.
    [7] Fact Sheet: Biden-Harris Administration’s Actions to Advance American Biotechnology and Biomanufacturing [EB/OL]. [2024-09-04]. https://www.whitehouse.gov/ ostp/news-updates/2024/06/25/fact-sheet-biden-harris-administrations-actions-to-advance-american-biotechnology-and-biomanufacturing.
    [8] Strategy Research on Research Infrastructures[EB/OL]. [2024-09-04]. https://roadmap2021.esfri.eu.
    [9] 骆建新, 郑崛村, 马用信, 张思仲. 人类基因组计划与后基因组时代[J]. 中国生物工程杂志, 2003, 23(11): 87-94. LUO JZ, ZHENG JC, Ma YX, ZHANG SZ. Human Genome Project and post-genome era[J]. Chinese Journal of Bioengineering, 2003, 23(11): 87-94(in Chinese).
    [10] Fact Sheet: human genome project[EB/OL]. [2024-09-04]. https://www.genome.gov/about-genomics/ educational-resources/fact-sheets/human-genome-project.
    [11] 郭振玺, 王晋, 张丽娜, 王荣荣, 黄春娟, 韩玉刚. 我国冷冻电镜平台建设现状及其发展[J]. 中国科技资源导刊, 2020, 52(6): 52-62. GUO ZX, WANG J, ZHANG LN, WANG RR, HUANG CJ, HAN YG. Recent development of cryo-electron microscopy core facilities in China[J]. China Science & Technology Resources Review, 2020, 52(6): 52-62(in Chinese).
    [12] 李建会, 李长华. 大数据驱动下的生命科学研究范式变革[J]. 哲学动态, 2023(10): 97-105. LI JH, LI ZH. The paradigm shift of big data-driven life science research[J]. Philosophical Trends, 2023(10): 97-105(in Chinese).
    [13] REGEV JERA. The legacy of the Human Genome Project[EB/OL]. [2023-12-18]. https://www.science. org/doi/10.1126/science.abl5403.
    [14] Strategy report on research infrastructures[EB/OL]. [2024-01-02]. http://roadmap2018.esfri.eu/media/1060/ esfri-roadmap-2018.pdf.
    [15] 阿儒涵, 吴丛, 李晓轩. 科研数据开放的国际实践及对我国的启示[J]. 中国科学院院刊, 2020, 35(1): 11-18. ARUHAN, WU C, LI XX. International practice of open research data and its enlightenment to China[J]. Bulletin of the Chinese Academy of Sciences, 2020, 35(1): 11-18(in Chinese).
    [16] 吴家睿. 确定性思维模式在生命科学领域面临的挑战[J]. 生命科学, 2023, 35(8): 977-983. WU JR. The challenges of deterministic thinking model in life sciences[J]. Chinese Bulletin of Life Science, 2023, 35(8): 977-983(in Chinese).
    [17] 邱晨辉. “生命天书”破译20年: 中国基因测序研究跻身世界前列[N]. 中国青年报, 2021-06-28. Qiu CH. "Book of Life" deciphered for 20 years China’s genetic sequencing research has joined the world’s forefront[N]. China Youth Daily, 2021-06-28(in Chinese).
    [18] About EMBL: We are Europe’s life sciences laboratory[EB/OL]. [2024-01-02]. https://www.embl. org/about.
    [19] 王璞玥, 任红艳, 李响, 孟庆峰, 郑永和, 冯雪莲, 杜生明. 推动生命科学发展的新技术新仪器研制的战略定位、发展趋势及重点资助方向[J]. 中国科学基金, 2016, 30(4): 291-297. WANG PY, REN HY, LI X, MENG QF, ZHENG YH, FENG XL, DU SM. Strategic orientation, development trend and key funding direction of the development of new technologies and instruments to promote the development of life sciences[J]. Bulletin of National Natural Science Foundation of China, 2016, 30(4): 291-297(in Chinese).
    [20] WEINBERG RA. Coming full circle-from endless complexity to simplicity and back again[J]. Cell, 2014, 157(1): 267-271.
    [21] NADDAF M. Europe spent €600 million to recreate the human brain in a computer: How did it go?[J]. Nature, 2023, 620(7975): 718-720.
    [22] 常旭华, 仲东亭. 国家实验室及其重大科技基础设施的管理体系分析[J]. 中国软科学, 2021(6): 13-22. CHANG XH, ZHONG DT. Study on management system of nation’s laboratory and its large research infrastructure[J]. China Soft Science, 2021(6): 13-22(in Chinese).
    [23] 张特, 陈若彤, 张兮, 张卫文. 合成生物学研发的风险类型分析: 基于Meta的分析[J]. 科学与社会, 2022, 12(3): 33-61. ZHANG T, CHEN RT, ZHANG X, ZHANG WW. Biosafety risk factors of synthetic biology research and application[J]. Science and Society, 2022, 12(3): 33-61(in Chinese).
    [24] 陈晓怡, 李宏, 茹志涛. 法国重大科技基础设施体系概况和建设模式及其启示[J]. 科技管理研究, 2022, 42(9): 22-30. CHEN XY, LI H, RU ZT. Overview and construction mode of major scientific and technological infrastructure in France and its enlightenment[J]. Science and Technology Management Research, 2022, 42(9): 22-30(in Chinese).
    [25] The impacts of large research infrastructures on economic innovation and on society[R/OL]. [2023-12-18]. https://cds.cern.ch/record/1708387/files/ CERN-case-studies.pdf.
    [26] 徐慧芳, 侯沁江, 陈思思, 袁军鹏, 李强. 国家重大科技基础设施的社会经济影响评估研究综述[J]. 科技管理研究, 2021, 41(13): 25-34. XU HF, HOU QJ, CHEN SS, YUAN JP, LI Q. Summary of research on socio-economic impact assessment of large research infrastructure[J]. Science and Technology Management Research, 2021, 41(13): 25-34(in Chinese).
    [27] 高也陶, 吴丽莉. 人类基因测序: 民间挑战政府[J].医学与哲学, 2002, 23(9): 26-30. Gao, Y, Wu, L. Human gene sequencing: Challenges from the civilian sector to the government. Medicine and Philosophy, 2002, 23(9): 26-30.
    [28] Group Technoplis. Review of the impacts of EMBL experimental services[R/OL]. [2023-12-18]. https://www.embl.org/documents/document/review-of-the-impacts-of-embl-experimental-services.
    [29] 周舟. 百余名美国科研领军人物反对限制中美科学交流[N]. 新华社, 2019-08-23. Zhou Z. Over a hundred leading American scientific figures oppose restrictions on Sino-US scientific exchanges[N]. Xinhua News Agency, 2019-08-23(in Chinese).
    [30] 国务院关于印发国家重大科技基础设施建设中长期规划(2012–2030年)的通知[EB/OL]. [2024-09-04]. https://www.gov.cn/zwgk/2013-03/04/content_2344891. htm.
    [31] 杨卫. 新时代中国基础研究决战“四个突破”[N]. 人民论坛网, 2017-12-12. Yang W. New era of China’s basic research aims for “four breakthroughs”. People’s Forum Online, 2017-12-12(in Chinese).
    [32] Grassano NHGH. The 2022 EU industrial R&D investment scoreboard[R/OL]. [2023-12-18]. https://iri.jrc.ec.europa.eu/scoreboard/2022-eu-industrial-rd-investment-scoreboard.
    [33] 李会红, 卢宇, 曾钢. 大科学装置科学研究联合基金十年资助管理工作综述[J]. 中国科学基金, 2019, 33(4): 367-374. Li H H, Lu Y, Zeng G. A review of the fund support and management of Joint Research Fund of large-scale scientific facility for ten years[J]. Bulletin of National Natural Science Foundation of China, 2019, 33(4): 367-374(in Chinese).
    [34] 美国国家科学院院士: 大国竞逐脑科学, 中国将上“快车道”[EB/OL]. [2024-09-04]. https://www. thepaper.cn/newsDetail_forward_1462491. 2016-04-28.
    [35] 吴家睿. 寻找生命健康大数据在安全保护与开放共享之间的平衡: 对《中华人民共和国个人信息保护法》的思考[J]. 生命科学, 2022, 34(1): 1-4. WU JR. Searching for the balance between security protection and open sharing of life and health big data-reflections on the personal information protection law of the People’s Republic of China[J]. Chinese Bulletin of Life Sciences, 2022, 34(1): 1-4(in Chinese).
    [36] 赵思宇. 2022年中国科学仪器行业全景图谱[R]. 前瞻产业研究院, 2022. ZHAO S Y. 2022 China Scientific Instrument Industry Panoramic Map[R]. Prospective Industry Research Institute, 2022(in Chinese).
    [37] 预见2022: 2022年中国科学仪器行业全景图谱[EB/OL]. [2024-09-04]. https://www.qianzhan.com/ analyst/detail/220/220107-ab7c0758.html.2022-01-09.
    [38] 樊潇潇. 国家重大科技基础设施宏观规划管理与决策机制研究[D]. 合肥: 中国科学技术大学博士学位论文, 2020. FAN XX. Research on macro-planning management and decision-making mechanism of national major science and technology infrastructure[D]. Hefei: Doctoral Dissertation of University of Science and Technology of China (in Chinese).
    [39] 葛焱, 杨文辉. “新基建” 背景下加强重大科技基础设施建设的思考[J]. 科学管理研究, 2021, 39(1): 45-50. GE Y, YANG WH. Thoughts on strengthening the construction of major scientific and technological infrastructure under the background of “new infrastructure”[J]. Scientific Management Research, 2021, 39(1): 45-50(in Chinese).
    [40] 章萍. 重大科技基础设施公私合作路径研究: 基于“伽利略”计划的启示[J]. 科学与社会, 2021, 11(1): 31-43. ZHANG P. Research on the path of public-private partnership in major scientific and technological infrastructure: based on the inspiration of the “Galileo” project[J]. Science and Society, 2021, 11(1): 31-43(in Chinese).
    [41] 常旭华. 上海发起或参与国际大科学计划和大科学工程的路径和运作方式[J]. 科学发展, 2021(7): 5-16. CHANG XH. The path and mode of operation for Shanghai to initiate or participate in international big science programs and big science projects[J]. Scientific Development, 2021(7): 5-16(in Chinese).
    [42] 樊建平. 蝴蝶模式: 大科学时代科研范式的创新探索: 基于中国科学院深圳先进技术研究院15年科学与产业融合发展的实践[J]. 中国科学院院刊, 2022, 37(5): 708-716. FAN JP. Butterfly pattern: innovative exploration of scientific research paradigm in era of big science-based on 15-year practice of integrated development of science and industry in Shenzhen institute of advanced technology (SIAT), Chinese Academy of Sciences[J]. Bulletin of Chinese Academy of Sciences, 2022, 37(5): 708-716(in Chinese).
    [43] 张毅, 闫强. 大科学的技术创新范式及演化动力分析[J]. 中国软科学, 2023(6): 1-25. ZHANG Y, YAN Q. Analysis of technology innovation paradigm and evolutionary dynamic of big science[J]. China Soft Science, 2023(6): 1-25(in Chinese).
    [44] 王立伟, 刘军, 张爱平, 于建荣. 长三角重大科技基础设施共建共享机制探索[J]. 科技导报, 2022, 40(9): 14-19. WANG LW, LIU J, ZHANG AP, YU JR. Exploration on co-construction and sharing mechanism of major science and technology infrastructure in Yangtze River Delta[J]. Science & Technology Review, 2022, 40(9): 14-19(in Chinese).
    [45] 左琛, 刘爽, 张弛, 王琦安. 发挥国际大科学工程优势培养、集聚和用好科技创新人才: 以平方公里阵列射电望远镜国际大科学工程研究为例[J]. 中国科技人才, 2022(2): 60-64. ZUO C, LIU S, ZHANG C, WANG QA. Give full play to the advantages of international megascience projects to cultivate, gather and make good use of science, technology and innovation talents: taking the SKA international mega-science project as an example[J]. Science and Technology Talents of China, 2022(2): 60-64(in Chinese).
    [46] 李宝智, 孙赫阳. 国际大科学工程组织模式选择及启示[J]. 全球科技经济瞭望, 2020, 35(2): 51-55. LI BZ, SUN HY. Organizational model choices of the international big science research projects and the enlightenment for China[J]. Global Science, Technology and Economy Outlook, 2020, 35(2): 51-55(in Chinese).
    相似文献
    引证文献
引用本文

乔黎黎. 生命领域重大科技基础设施发展特征、问题与对策[J]. 生物工程学报, 2024, 40(9): 2968-2982

复制
相关视频

分享
文章指标
  • 点击次数:190
  • 下载次数: 688
  • HTML阅读次数: 547
  • 引用次数: 0
历史
  • 收稿日期:2023-11-27
  • 最后修改日期:2023-12-18
  • 在线发布日期: 2024-09-24
  • 出版日期: 2024-09-25
文章二维码
您是第位访问者
生物工程学报 ® 2025 版权所有

通信地址：中国科学院微生物研究所    邮编：100101

电话：010-64807509   E-mail：cjb@im.ac.cn

技术支持：北京勤云科技发展有限公司